多肽：化学、生物学和药物科学（全英文会议论文）

多肽：化学、生物学和药物科学（全英文会议论文）
出版时间：2011年版
内容简介
　　The 11th Chinese International Peptide Symposium （CPS-2010）， hosted by Lanzhou University， was held in Lanzhou， China， July 5-8， 2010. More than 300 participants， from 12 countries and districts as well as represents from 30 or so related companies attended this symposium. Thus， it was gratifying to see that this meeting retained both its international flavor and participants loyalty at a time when there are a great many symposia held each year on similar subjects. The goal of this symposium was to provide a forum for exchange of ideas， review of the progress in the field of peptide research， encourage the cooperation between the international and Chinese scientific communities. We believe that this goal had been achieved.The scientific program， thanks to the insights and efforts of the program committee， was extraordinary rich， diverse and exciting. It was comprised of 14 sessions with 22 plenary lectures， 37 invited lectures and 116 poster presentations， concerning bioactive peptides， peptide immunology， structure and conformation of peptides and proteins， molecular diversity and peptide libraries， synthetic methods， de novo design and synthesis of proteins and peptides， ligand-receptor interactions， the chemistry-biology-interface， self-assembling peptides and challenging problems in peptides.Dr. John D. Wade and Dr. Yanmei Li were the recipients of ‘Cathay Award’ sponsored by H. H. Liu Education Foundation， offering their seminal contributions to peptide science and the Chinese International Peptide Symposium. Dr. Saburo Aimoto and Dr. Luhua Lai were the recipients of ‘Xiaoyu Hu Memorial Award’ sponsored by Hainan Zhonghe （Group） Co. Ltd， offering their great contributions in peptide science， peptide application and Chinese International Peptide Symposium. Especially， it should be mentioned that ‘Xiaoyu Hu Memorial Award’ was first set up at the 11th CPS to commemorate Professor Xiaoyu Hu for his great contribution to the development of peptide science and peptide application in China. Four young outstanding scientists were selected by the International Program Committee to receive the Young Peptide Scientist Award ， which was sponsored by Hainan Zhonghe （Group） Co. Ltd.The enthusiastic cooperation and prominent contributions were gratifying and the active response of the invited speakers contributed to the success of the symposium. The presentations were of excellent caliber and represented the most current and significant aspects of peptide science.I would like to acknowledge academicians of chinese academy of sciences， Professor Youshang Zhang and Professor Yundong Wu for their kindness in supporting and serving as the chairman of the awarding committee for the ‘Cathay Award’ and ‘Xiaoyu Hu Memorial Award’ respectively. The success of the 11th CPS was largely due to the dedication， enthusiasm and hard work of the local organizing committee， who for the most part consisted of volunteers. As Symposium Chair， I am appreciated for their contributions very much.
目录
Preface Ⅴ
The Eleventh Chinese Peptide Symposium (CPS-2010) Ⅶ
Acknowledgments Ⅹ
Cathay Award Ⅺ
Xiaoyu Hu Memorial Award Ⅻ
Chinese Peptide Symposium ⅩⅢ
Abbreviations ⅩⅣPreface
The Eleventh Chinese Peptide Symposium (CPS-2010)
Acknowledgments
Cathay Award
Xiaoyu Hu Memorial Award
Chinese Peptide Symposium
Abbreviations
Session 1 Design of Peptides and Mimetics 1
Biomimetic Nanostructures Based on Enforced Folding and Assembly3
Bing Gong
Agonist vs. Antagonist Behavior of Opioid Peptides ContainingNovel
Tyrosine or Phenylalanine Analogues in Place of Tyr1 13
Grazyna Weltrowska, Irena Berezowska, Brian C. Wilkes, CaroleLemieux,
Nga N. Chung, Jinguo Ding, Yixin Lu, Peter W. Schiller,
Novel Non-Peptide Ghrelin Receptor Ligands Based on
3,4,5-Trisubstituted 1,2,4-Triazoles 20
Jean-Alain Fehrentz, Anne-Laure Blayo, Mathieu Bibian, AlineMoulin, Luc
Demange, Damien Boeglin, Céline M’Kadmi, Jean-ClaudeGalleyrand,
Didier Gagne, Vittorio Locatelli, Antonello Torsello, DanielPerrissoud,
Jean Martinez,
Synthesis and Structure-Activity Relationship ofMarinostatin,
An Ester-Linked Serine Protease Inhibitor 25
Misako Taichi, Toshimasa Yamazaki, Tadashi Teshima, YujiNishiuchi
Mitocryptides: A Novel Family of Neutrophil-Activating PeptidesDerived
from Mitochondrial Proteins and Their Regulatory Mechanisms30
Hidehito Mukai, Tetsuo Seki, Akiyoshi Fukamizu, Yoshiaki Kiso
Novel Opioid Peptide Derived Antagonists Containing 3-(2,6-Dimethyl-4-
Carbamoylphenyl)-Propanoic Acid (Dcp) in Place of Tyr1 33
Peter W. Schiller, Grazyna Weltrowska, Thi M.-D. Nguyen, CaroleLemieux,
Nga N. Chung, Tze Keong Lum, Yoon Wui Leow Augustine, YixinLu
Design, Synthesis and Evaluation of Antitumor Activityagainst
Human Cancer Cell Lines, Sansalvamide Analogues 39
Xiaoli Zhen, Yihua Yang, Junzhang Li, Xia Tian, Hua Zhang, ShouxinLiu
Session 2 Peptide Synthesis and Preparation 41
Regioselective Disulfide Bond Formation during SPS of HumanRelaxin-3:
Evaluation of An Alternative Method for Removal of the S-Acm Groupsvia
Reaction with Silver Triflate and Subsequent Mild Aqueous
DMSO Oxidation 43
Feng Lin, John D. Wade
Synthetic Studies of Membrane Proteins: Subunit C of HumanF1Fo-ATP
Synthase and Voltage Sensor Only Protein (78-222) 47
Saburo Aimoto, Ken’ichiro Nakamura, Takeshi Sato, ToruKawakami,
Toshiaki Hara
One-Pot Synthesis of Rigid Cyclic N-Methyl-γ-Peptides 54
Zhongzhu Chen, Liangchun Li, Menglan Lv, Jin Zhu and JingenDeng
Tbfmoc Methioine: Its Synthesis and Application for the SolidPhase
Synthesis of Ubiquitin Analogues and Product Purification 58
Naifeng Hu, Zhi Jin, Pu Wang
Intein-Mediated Biosynthesis of Bracelet Cyclotide 63
Xinya Hemu, Lin Cai, Clarence T. T. Wong, James P. Tam
Convergent and Atom-Economic Synthesis of Phosphinopeptides67
Fanhua Meng, Jiaxi Xu
One-Step Oxidative Folding of A Novel Cystine-Knot Cyclotide
Under Denaturation Conditions 69
Clarence T. T. Wong, Misako Taichi, Hideki Nishio, YujiNishiuchi,
James P. Tam
Synthesis of Angiotensin I-Converting Enzyme Inhibitory Peptidesand
Their Self-Assembling Microstructure Characterization 72
Dawei Li, Yan Ding, Gang Cao, Ruijie Zhang, Jin Ren, ChuanguangQin
Fast Automated Synthesis of An Antimicrobial Peptide Analog
Using UV-Monitoring on the Tribute? 77
German E. Fuentes, Christina A. Chantell, Hirendra Patel,Mahendra
Menakuru
Synthesis of Cyclic Peptides by Alknye-Azide Click ChemistryCyclization 81
Liangyou Wang, Dongdong Lu, Mingxing Lu
Thioester Preparation through O-S Acyl Shift under Acidic Condition83
Khee Dong Eom, Young Soon Shin, James P. Tam
A Novel Strategy for Total Solid-Phase Synthesis of
Kahalalide A Derivatives 86
Tingting Wei, Jin Ren, Xiaoya Shang, Gang Cao, Chuanguang Qin
Session 3 Methodologies in Peptide Research 91
Protein Synthesis Using Novel Ligation Partners 93
Wen Hou, Renliang Yang, Fupeng Li, Xiaohong Zhang, ChuanfaLiu
Expanding Role of Mass Spectrometry for Characterization ofProteins 97
Pui-kin So, Zhongping Yao
Effect of pH on the Self-Assembly of Surfactant-Like Peptides102
Shuyi Han, Jing Wang, Hai Xu
Conformational Isomers in N-Methylzygosporamide CyclicPentapeptides 110
Yihua Yang, Shirui Gao, Xianrui Yuan, Shouxin Liu, Wei Meng, GuodiQi
Interaction between Amyloid-β-Peptide (1-40) and ItsAggregation
Inhibitors Studied by Circular Dichroism 112
Qing Zeng
Disulfide Bond Formation Directed by Watson-Crick Base Pairing116
Fupeng Li, Xiaohong Zhang, Wen Hou, Chuanfa Liu
Interfacial Adsorption of Novel Lipopeptide Surfactant C14K3: ACombined
Study of Spectroscopic Ellipsometry and Neutron Reflection120
Donghui Jia, Kai Tao, Jiqian Wang, Xiubo Zhao, Hai Xu, John R.P.
Webster, Jian R. Lu
Session 4 Peptide Therapeutics and Application 135
Peptide-Based Nanoparticles for Cancer Therapy and Imaging137
Yuanpei Li, Kai Xiao, Juntao Luo, Wenwu Xiao, Joyce Lee,
Lorenzo Berti, Kit S. Lam
Involvement of Na+,K+-ATPase in Leukemia Cell Apoptosis
by Modulating Sensitivity 145
Wu Yin, Wei Cheng, Wei Chen, Dan Cao, Su Feng, Xinyin Chen, JinZhao,
Yilin Shi, Zichun Hua
Short Constrained Dipeptide Mimic Oligomers as Uncharged Cell
Penetrating Compounds 157
Lubomir L. Vezenkov, Christophe André, David Paramelle, MarieMaynadier,
Jean-Francois Hernandez, Marcel Garcia, Monique Calmès, GillesSubra,
Ettore Benedetti, Jean Martinez, Muriel Amblard
Synthesis and Biological Properties of Peptide-siRNA Conjugates161
Zhenjun Yang, Xiaofeng Wang, Yang Liu, Yue Chen, Feilin Nie, LiheZhang
FGF-P Facilitates Cell Proliferation Following Ionizing Radiation167
Yeping Tian, Shanmin Yang, Mei Zhang, Yongbing Cao, BingrongZhang,
Lei Zhang, Liangjie Yin, Kunzhong Zhang, Steven G. Stwarts, BruceM.
Fentona, Paul Okunieff, Lurong Zhang
Synthesis, Evaluation and Molecular Modeling Study ofL-2-amino-7/8-
Bromoalkanoic Acid Derivatives as Histone Deacetylase Inhibitors172
Dawei Huang, Xiaohui Li , Zhilong Xiu, Norikazu Nishino
Thirteen-Membered Cyclic Tetrapeptides as Histone DeacetylaseInhibitors 177
Hongfang Chi, Yasuhiko Otsuka, Tamaki Kato, Norikazu Nishino,
Akihiro Ito, Minoru Yoshida
Antimicrobial Peptide May be Desirable Candidate for the Treatmentof
Multidrug-Resistant Cancer & Bacteria: A Simple Introduction tothe
Therapeutic Effects of A Novel Antimicrobial Peptide Polybia-MPI182
Kairong Wang, Bangzhi Zhang, Jiexi Yan, Wei Zhang, Ru Chen,
Jingjing Song, Rui Wang
Remodeling of Cyclic Tetrapeptides Framework of Chlamydocinas
Histone Deacetylase Inhibitors 188
Jiani Li, Xiaohui Li, Yasuhiko Otsuka, Tamaki Kato, NorikazuNishino,
Akihiro Ito, Minoru Yoshida
Identification of Novel HLA-A*0201-Restricted Cytotoxic T
lymphocyte Epitopes from PLAC1 in Breast Cancer 192
Wei Liu, Mingxia Zhai, Chao Dai, Yuanming Qi, Yanfeng Gao
Session 5 Bioactive Peptides and Pharmacology 197
In Vitro Characterization for the Effects of Insect Kinins onMouse
Distal Colonic Motility 199
Longfei Yang, Yang Xiao, Yun Huang, Guoning Ma, Zhiyuan Cong,
Shouliang Dong
Evaluation of the Bioequivalence of the 20 mg /10 ml Doses ofTwo
Injectable Preparations of Eptifibatide: A Randomized,Open-Label,
Two-Period Crossover Study in Healthy Adult Male Chinese Volunteers204
Yanhui Gao, Baoqiu Li, Jun Sun
The Characteristics of Sleep-Wake States and PotentialNeuronal
Targets for Neuropeptide S 210
Peng Zhao, Yufeng Shao, Min Zhang, Kun Fan, Rui Wang, YipingHou
Antibacterial Activity of Surfactant-Like Linear Amphipathic
Cationic Peptides 218
Jing Hu, Cui X. Chen, Sheng Z. Zhang, Hai Xu, Jian R. Lu
Comparison of the Pharmacological Functions of the NPFF1
and NPFF2 Receptors Ligands 229
Quan Fang, Ning Li, Rui Wang
Preparation of Monomeric B27 Lys Destripeptide Insulin by
Intein Mediated Expression in E. Coli 236
Lujuan Li, Helong Hao, Yuanhao Qiao, Ting Chen
Endomorphins Prevent Cardiac Oxidative Damage Induced
by Cadmium Chloride in Rats 241
Pin Gong, Fuxin Chen, Rui Wang
Study on Anticancer Mechanism of Cyclic Tetrapeptide HDACIs246
Shimiao Wang, Xiaohui Li, Zhilong Xiu, Norikazu Nishino 246
Biological Roles of Hemokinin-1: A Novel Member of
the Tachykinin Family 251
Ziqing Kong, Wenle Yang, Caiyun Fu, Youli Zhao, Yan Tao, RuiWang
Author Index 257
Subject Index 260
Session 1 Design of Peptides and Mimetics
Biomimetic Nanostructures Based on Enforced Folding andAssembly
Bing Gong
Agonist vs. Antagonist Behavior of Opioid Peptides ContainingNovel
Tyrosine or Phenylalanine Analogues in Place of Tyr1
Grazyna Weltrowska, Irena Berezowska, Brian C. Wilkes, CaroleLemieux,
Nga N. Chung, Jinguo Ding, Yixin Lu, Peter W. Schiller,
Novel Non-Peptide Ghrelin Receptor Ligands Based on
3,4,5-Trisubstituted 1,2,4-Triazoles
Jean-Alain Fehrentz, Anne-Laure Blayo, Mathieu Bibian, AlineMoulin, Luc
Demange, Damien Boeglin, Céline M’Kadmi, Jean-ClaudeGalleyrand,
Didier Gagne, Vittorio Locatelli, Antonello Torsello, DanielPerrissoud,
Jean Martinez,
Synthesis and Structure-Activity Relationship ofMarinostatin,
An Ester-Linked Serine Protease Inhibitor
Misako Taichi, Toshimasa Yamazaki, Tadashi Teshima, YujiNishiuchi
Mitocryptides: A Novel Family of Neutrophil-Activating PeptidesDerived
from Mitochondrial Proteins and Their Regulatory Mechanisms
Hidehito Mukai, Tetsuo Seki, Akiyoshi Fukamizu, Yoshiaki Kiso
Novel Opioid Peptide Derived Antagonists Containing 3-(2,6-Dimethyl-4-
Carbamoylphenyl)-Propanoic Acid (Dcp) in Place of Tyr1
Peter W. Schiller, Grazyna Weltrowska, Thi M.-D. Nguyen, CaroleLemieux,
Nga N. Chung, Tze Keong Lum, Yoon Wui Leow Augustine, YixinLu
Design, Synthesis and Evaluation of Antitumor Activityagainst
Human Cancer Cell Lines, Sansalvamide Analogues
Xiaoli Zhen, Yihua Yang, Junzhang Li, Xia Tian, Hua Zhang, ShouxinLiu
Session 2 Peptide Synthesis and Preparation
Regioselective Disulfide Bond Formation during SPS of HumanRelaxin-3:
Evaluation of An Alternative Method for Removal of the S-Acm Groupsvia
Reaction with Silver Triflate and Subsequent Mild Aqueous
DMSO Oxidation
Feng Lin, John D. Wade
Synthetic Studies of Membrane Proteins: Subunit C of HumanF1Fo-ATP
Synthase and Voltage Sensor Only Protein (78-222)
Saburo Aimoto, Ken’ichiro Nakamura, Takeshi Sato, ToruKawakami,
Toshiaki Hara
One-Pot Synthesis of Rigid Cyclic N-Methyl-γ-Peptides
Zhongzhu Chen, Liangchun Li, Menglan Lv, Jin Zhu and JingenDeng
Tbfmoc Methioine: Its Synthesis and Application for the SolidPhase
Synthesis of Ubiquitin Analogues and Product Purification
Naifeng Hu, Zhi Jin, Pu Wang
Intein-Mediated Biosynthesis of Bracelet Cyclotide
Xinya Hemu, Lin Cai, Clarence T. T. Wong, James P. Tam
Convergent and Atom-Economic Synthesis of Phosphinopeptides
Fanhua Meng, Jiaxi Xu
One-Step Oxidative Folding of A Novel Cystine-Knot Cyclotide
Under Denaturation Conditions
Clarence T. T. Wong, Misako Taichi, Hideki Nishio, YujiNishiuchi,
James P. Tam
Synthesis of Angiotensin I-Converting Enzyme Inhibitory Peptidesand
Their Self-Assembling Microstructure Characterization
Dawei Li, Yan Ding, Gang Cao, Ruijie Zhang, Jin Ren, ChuanguangQin
Fast Automated Synthesis of An Antimicrobial Peptide Analog
Using UV-Monitoring on the Tribute?
German E. Fuentes, Christina A. Chantell, Hirendra Patel,Mahendra
Menakuru
Synthesis of Cyclic Peptides by Alknye-Azide Click ChemistryCyclization
Liangyou Wang, Dongdong Lu, Mingxing Lu
Thioester Preparation through O-S Acyl Shift under AcidicCondition
Khee Dong Eom, Young Soon Shin, James P. Tam
A Novel Strategy for Total Solid-Phase Synthesis of
Kahalalide A Derivatives
Tingting Wei, Jin Ren, Xiaoya Shang, Gang Cao, Chuanguang Qin
Session 3 Methodologies in Peptide Research
Protein Synthesis Using Novel Ligation Partners
Wen Hou, Renliang Yang, Fupeng Li, Xiaohong Zhang, ChuanfaLiu
Expanding Role of Mass Spectrometry for Characterization ofProteins
Pui-kin So, Zhongping Yao
Effect of pH on the Self-Assembly of Surfactant-Like Peptides
Shuyi Han, Jing Wang, Hai Xu
Conformational Isomers in N-Methylzygosporamide CyclicPentapeptides
Yihua Yang, Shirui Gao, Xianrui Yuan, Shouxin Liu, Wei Meng, GuodiQi
Interaction between Amyloid-β-Peptide (1-40) and ItsAggregation
Inhibitors Studied by Circular Dichroism
Qing Zeng
Disulfide Bond Formation Directed by Watson-Crick BasePairing
Fupeng Li, Xiaohong Zhang, Wen Hou, Chuanfa Liu
Interfacial Adsorption of Novel Lipopeptide Surfactant C14K3: ACombined
Study of Spectroscopic Ellipsometry and Neutron Reflection
Donghui Jia, Kai Tao, Jiqian Wang, Xiubo Zhao, Hai Xu, John R.P.
Webster, Jian R. Lu
Session 4 Peptide Therapeutics and Application
Peptide-Based Nanoparticles for Cancer Therapy and Imaging
Yuanpei Li, Kai Xiao, Juntao Luo, Wenwu Xiao, Joyce Lee,
Lorenzo Berti, Kit S. Lam
Involvement of Na+,K+-ATPase in Leukemia Cell Apoptosis
by Modulating Sensitivity
Wu Yin, Wei Cheng, Wei Chen, Dan Cao, Su Feng, Xinyin Chen, JinZhao,
Yilin Shi, Zichun Hua
Short Constrained Dipeptide Mimic Oligomers as Uncharged Cell
Penetrating Compounds
Lubomir L. Vezenkov, Christophe André, David Paramelle, MarieMaynadier,
Jean-Francois Hernandez, Marcel Garcia, Monique Calmès, GillesSubra,
Ettore Benedetti, Jean Martinez, Muriel Amblard
Synthesis and Biological Properties of Peptide-siRNAConjugates
Zhenjun Yang, Xiaofeng Wang, Yang Liu, Yue Chen, Feilin Nie, LiheZhang
FGF-P Facilitates Cell Proliferation Following IonizingRadiation
Yeping Tian, Shanmin Yang, Mei Zhang, Yongbing Cao, BingrongZhang,
Lei Zhang, Liangjie Yin, Kunzhong Zhang, Steven G. Stwarts, BruceM.
Fentona, Paul Okunieff, Lurong Zhang
Synthesis, Evaluation and Molecular Modeling Study ofL-2-amino-7/8-
Bromoalkanoic Acid Derivatives as Histone DeacetylaseInhibitors
Dawei Huang, Xiaohui Li , Zhilong Xiu, Norikazu Nishino
Thirteen-Membered Cyclic Tetrapeptides as Histone DeacetylaseInhibitors
Hongfang Chi, Yasuhiko Otsuka, Tamaki Kato, Norikazu Nishino,
Akihiro Ito, Minoru Yoshida
Antimicrobial Peptide May be Desirable Candidate for the Treatmentof
Multidrug-Resistant Cancer & Bacteria: A Simple Introduction tothe
Therapeutic Effects of A Novel Antimicrobial PeptidePolybia-MPI
Kairong Wang, Bangzhi Zhang, Jiexi Yan, Wei Zhang, Ru Chen,
Jingjing Song, Rui Wang
Remodeling of Cyclic Tetrapeptides Framework of Chlamydocinas
Histone Deacetylase Inhibitors
Jiani Li, Xiaohui Li, Yasuhiko Otsuka, Tamaki Kato, NorikazuNishino,
Akihiro Ito, Minoru Yoshida
Identification of Novel HLA-A*0201-Restricted Cytotoxic T
lymphocyte Epitopes from PLAC1 in Breast Cancer
Wei Liu, Mingxia Zhai, Chao Dai, Yuanming Qi, Yanfeng Gao
Session 5 Bioactive Peptides and Pharmacology
In Vitro Characterization for the Effects of Insect Kinins onMouse
Distal Colonic Motility
Longfei Yang, Yang Xiao, Yun Huang, Guoning Ma, Zhiyuan Cong,
Shouliang Dong
Evaluation of the Bioequivalence of the 20 mg /10 ml Doses ofTwo
Injectable Preparations of Eptifibatide: A Randomized,Open-Label,
Two-Period Crossover Study in Healthy Adult Male ChineseVolunteers
Yanhui Gao, Baoqiu Li, Jun Sun
The Characteristics of Sleep-Wake States and PotentialNeuronal
Targets for Neuropeptide S
Peng Zhao, Yufeng Shao, Min Zhang, Kun Fan, Rui Wang, YipingHou
Antibacterial Activity of Surfactant-Like Linear Amphipathic
Cationic Peptides
Jing Hu, Cui X. Chen, Sheng Z. Zhang, Hai Xu, Jian R. Lu
Comparison of the Pharmacological Functions of the NPFF
and NPFF2 Receptors Ligands
Quan Fang, Ning Li, Rui Wang
Preparation of Monomeric B27 Lys Destripeptide Insulin by
Intein Mediated Expression in E. Coli
Lujuan Li, Helong Hao, Yuanhao Qiao, Ting Chen
Endomorphins Prevent Cardiac Oxidative Damage Induced
by Cadmium Chloride in Rats
Pin Gong, Fuxin Chen, Rui Wang
Study on Anticancer Mechanism of Cyclic Tetrapeptide HDACIs
Shimiao Wang, Xiaohui Li, Zhilong Xiu, Norikazu Nishino
Biological Roles of Hemokinin-1: A Novel Member of
the Tachykinin Family
Ziqing Kong, Wenle Yang, Caiyun Fu, Youli Zhao, Yan Tao, RuiWang
Author Index
Subject Index