生物化学 英文改编版 第2版 作者：（美)罗伯特·K·默里(Robert K. Murray)等著；汤其群改编 出版时间： 2019年版 丛编项： 中国科学院教材建设专家委员会规划教材·医学英文原版改编双语教材 内容简介 Original language published by the Mc Graw-Hill Companies， Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means， electronic or mechanical， including photocopying， recording， taping， or any information and retrieval system， without the written permission of the publisher.This authorized English language adapted edition is jointly published by Mc Graw-Hill Education（Asia）Co. and Science Press. This edition is authorized for sale in the People’s Republic of China only， excluding Hong Kong SAR， Macao SAR and Taiwan province of China. Unauthorized export of this edition is a violation of the Copyright Act. Violation of this Law is subject to Civil and Criminal Penalties.《生物化学（英文改编版，第2版）》英文影印改编版由科学出版社和美国麦格劳 - 希尔教育（亚洲）出版公司合作出版。未经出版者预先书面许可，不得以任何方式复制或抄袭《生物化学（英文改编版，第2版）》的任何内容。此版本仅限在中华人民共和国境内（不包括香港、澳门特别行政区及台湾省）销售。未经许可之出口，视为违反著作权法，将受法律之制裁。 目录 CONTENTS CHAPTER 1 STRUCTURES & FUNCTIONS OF PROTEINS 1 1 AMINO ACIDS & PEPTIDES 1 2 PROTEINS: PRIMARY STRUCTURE 8 3 PROTEINS: HIGHER ORDERS OF STRUCTURE 14 4 PROTEINS: MYOGLOBIN & HEMOGLOBIN 24 CHAPTER 2 STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS 33 1 CHEMICAL COMPONENTS OF NUCLEIC ACIDS 33 2 DNA CARRIES THE GENETIC INFORMATION 37 3 CHEMICAL NATURE OF RNA DIFFERS FROM THAT OF DNA 39 4 ESSENCIAL PROPERTIES OF NUCLEIC ACIDS 45 5 BIOLOGICAL FUNCTIONS OF NUCLEIC ACIDS 46 CHAPTER 3 STRUCTURE AND FUNCTION OF ENZYME 51 1 GENERAL PROPERTIES OF ENZYME 51 2 MECHANISM OF ACTION OF ENZYMES AND COENZYMES 55 3 KINETICS OF ENZYMATIC REACTIONS 62 4 REGULATION OF ENZYME ACTIVITIES 69 CHAPTER 4 METABOLISM OF CARBOHYDRATES 77 1 CARBOHYDRATES & ITS DIGESTION/ABSORPTION 77 2 GLYCOLYSIS 78 3 AEROBIC OXIDATION OF GLUCOSE 84 4 PENTOSE PHOSPHATE PATHWAY & OTHER PATHWAYS OF HEXOSE METABOLISM 93 5 METABOLISM OF GLYCOGEN 103 6 GLUCONEOGENESIS & THE CONTROL OF BLOOD GLUCOSE 111 CHAPTER 5 METABOLISM OF LIPIDS 121 1 LIPIDS OF PHYSIOLOGIC SIGNIFICANCE 121 2 OXIDATION OF FATTY ACIDS 128 3 BIOSYNTHESIS OF FATTY ACIDS 137 4 METABOLISM OF TRIGLYCERIDES 144 5 METABOLISM OF CHOLESTEROL 146 6 METABOLISM OF PHOSPHOLIPIDS 150 7 LIPID TRANSPORT & STORAGE 152 CHAPTER 6 BIOENERGETICS 163 1 BIOENERGETICS: THE ROLE OF ATP 163 2 BIOLOGIC OXIDATION 168 3 THE MITOCHONDRIAL RESPIRATORY CHAIN & OXIDATIVE PHOSPHORYLATION 172 CHAPTER 7 METABOLISM OF AMINO ACID 184 1 THE NUTRITIONAL VALUE， DIGESTION & ABSORPTION OF PROTEIN 184 2 CATABOLISM OF PROTEINS & AMINO ACIDS 186 3 CATABOLISM OF THE CARBON SKELETONS OF AMINO ACIDS 195 4 CONVERSION OF AMINO ACIDS TO SPECILIZED PRODUCTS 210 CHAPTER 8 METABOLISM OF PURINE & PYRIMIDINE NUCLEOTIDES 219 1 BIOSYNTHESIS OF PURINE NUCLEOTIDES 219 2 DEGRADATION OF PURINE NUCLEOTIDES 223 3 BIOSYNTHESIS OF PYRIMIDINE NUCLEOTIDES 224 4 CATABOLISM OF PYRIMIDINES PRODUCES WATER-SOLUBLE METABOLITES 226 CHAPTER 9 DNA REPLICATION & REPAIR 228 1 DNA REPLICATION 228 2 DNA REPAIR 238 CHAPTER 10 RNA SYNTHESIS， PROCESSING & MODIFICATION 242 1 RNA SYNTHESIS 242 2 RNA PROCESSING & MODIFICATION 252 CHAPTER 11 REGULATION OF GENE EXPRESSION 259 BIOMEDICAL IMPORTANCE 259 1 OUTLINE OF GENE EXPRESSION REGULATION 259 2 GENE EXPRESSION REGULATION IN PROKARYOTIC 267 3 GENE EXPRESSION REGULATION IN EUKARYOTES 274 CHAPTER 12 PROTEIN BIOSYNTHESIS 282 BIOMEDICAL IMPORTANCE 282 1 SYSTEM OF PROTEIN SYNTHESIS 282 2 PROTEIN SYNTHESIS CAN BE DESCRIBED IN THREE PHASES: INITIATION， ELONGA TION & TERMINATION 285 3 BIOMEDICINE SIGNIFICANCY OF PROTEIN SYNTHESIS 292 4 INTRACELLULAR TRAFFIC & SORTING OF PROTEINS 297 5 PROTEIN FOLDING AND DEGRA- DATION AS WELL AS ASSAMBLY OF MEMBRANCE 307 CHAPTER 13 ESSENCIAL TECHNIQUES FOR MOLECULAR BIOLOGY 317 1 RECOMBINANT DNA TECHNOLOGY INVOLVES ISOLATION AND MANIPULATION OF DNA 317 2 PRACTICAL APPLICATIONS OF RECOMBINANT DNA TECHNOLOGY ARE NUMEROUS 328 CHAPTER 14 BIOCHEMISTRY OF EXTRACELLULAR & INTRACELLULAR COMMUNI-CATION 336 1 MEMBRANES: STRUCTURE & FUNCTION 336 2 THE DIVERSITY OF THE ENDOCRINE SYSTEM 356 3 HORMONE ACTION & SIGNAL TRANSDUCTION 359 CHAPTER 15 NUTRIENTS: VITAMINS & MINERALS 377 1 LIPID-SOLUBLE VITAMINS 377 2 WATER-SOLUBLE VITAMINS 384 CHAPTER 16 FREE RADICALS AND ANTIOXIDANT NUTRIENTS 394 1 FREE RADICALS 394 2 ANTIOXIDANT NUTRIENTS 396 CHAPTER 17 GLYCOPROTEINS 399 1 OVERVIEW OF GLYCOPROTEIN 399 2 STRUCTURE AND FUNCTION OF GLYCAN IN GLYCOPROTEIN 403 CHAPTER 18 THE EXTRACELLULAR MATRIX 421 1 STRUCTURE AND FUNCTION OF COLLAGEN & ELASTIN 421 2 STRUCTURE AND FUNCTION OF FIBRONECTIN & LAMIN 426 3 STRUCTURE AND FUNCTION OF GLYCOSAMINOGLYCANS & PROTEOGLYCANS 428 4 BONE AND CARTILAGE 435 CHAPTER 19 PLASMA PROTEINS & IMMUNOGLOBULINS 442 1 THE FUNCTIONS OF THE MAJOR PLASMA PROTEINS 442 2 PLASMA PROTEINS INVOLVED IN MAINTAINING IRON HOMEOSTASIS 447 3 PLASMA IMMUNOGLOBULINS 459 CHAPTER 20 METABOLISM OF XENOBIOTICS 466 1 INTRODUCTION 466 2 BIOTRANSFORMATION 466 CHAPTER 21 CANCER: AN OVERVIEW 471 1 INTRODUCTION 471 2 ONCOGENES， TUMOR SUPPRESSOR GENES AND GROWTH FACTORS 472 3 THE MOLECULAR MECHANISMS OF TUMORIGENESIS 476 CHINESE-ENGLISH GLOSSARY 486
